PT740. Prediction of Circadian Clock with Combination of One point Expression Profiles of Ten Circadian Clock Genes of Circadian rhythm Prediction Model

s | 69 analysis with structural equation modeling was performed for correlation between Japanese diet and health. As the result of the trend test, intake of rice and miso (fermented soybean paste) was correlated with sleep quality (trend p=0.006 and 0.003, respectively) and rice consumption is also correlated with impulsiveness (trend p=0.007). Fish consumption was correlated with impulsiveness (trend p=0.027). The path analysis indicated that rice consumption improves impulsiveness, depressiveness and sleep quality via indirect effect of miso consumption (p values for sum of indirect were 0.046, 0.037 and 0.010, respectively). The statistical analysis didn’t show direct effect of bread consumption on physical and mental health, as well as the path analysis showed no significant fit for the indirect effect between bread consumption via miso consumption. Thus, rice-based diet, especially with miso consumption, is suggested to maintain mental health. PT739 Rice is nice: benefits of rice consumption for brain health Minori Koga, Yoshinobu Kiso, Ichiro Kusumi, Atsuhito Toyomaki Hokkaido University, Japan Abstract Previous our investigation has suggested that Japanese diet is associated with mental health and specified that rice, miso (soybean paste) and fish consumption affected to quality of life, sleep quality, impulsiveness and depressiveness. Furthermore, the study showed combination of rice and miso was supposed to be associated to mental and physical health. The Japanese diet consists of rice and other dishes with vegetable, fish and meat. Combinations of rice and other dishes have been developed over the centuries in order to have nutritionally balanced diet. We hypothesized rice-based diet impacts mental and physical health and investigate the consequences of dietary intervention of rice. The study is a randomized, open trial, parallel-groups clinical trial where 60 participants were screened with inclusion criteria, which is (1) eating regularly 3 meals per day and (2) eating staple foods other than rice one or more times. Participants were randomly assigned to have rice-based meals or no rice-centered meals for 3 dairy meals for 2 months. Participants were surveyed sleep quality, quality of life, anxiety scale and dietary pattern before and after the experimental period. As well as questionnaire surveys, biochemical changes focusing on orexin A, cortisol and eotaxin-1 were measured in the blood. The sleep quality index scores showed improvement after the intervention of rice-based meal. In addition to the subjective assessment, blood plasma eotaxin-1 levels substantially reduced by the intervention. Several molecular studies demonstrated that eotaxin-1 impaired neurogenesis, synaptic plasticity and cognition, thus the molecule is suggested negative modifier of central nervous system. Although the relationship between sleep quality and blood plasma eotaxin-1 level has not been cleared so far, findings of the present study support that rice-based diet benefits brain health.Previous our investigation has suggested that Japanese diet is associated with mental health and specified that rice, miso (soybean paste) and fish consumption affected to quality of life, sleep quality, impulsiveness and depressiveness. Furthermore, the study showed combination of rice and miso was supposed to be associated to mental and physical health. The Japanese diet consists of rice and other dishes with vegetable, fish and meat. Combinations of rice and other dishes have been developed over the centuries in order to have nutritionally balanced diet. We hypothesized rice-based diet impacts mental and physical health and investigate the consequences of dietary intervention of rice. The study is a randomized, open trial, parallel-groups clinical trial where 60 participants were screened with inclusion criteria, which is (1) eating regularly 3 meals per day and (2) eating staple foods other than rice one or more times. Participants were randomly assigned to have rice-based meals or no rice-centered meals for 3 dairy meals for 2 months. Participants were surveyed sleep quality, quality of life, anxiety scale and dietary pattern before and after the experimental period. As well as questionnaire surveys, biochemical changes focusing on orexin A, cortisol and eotaxin-1 were measured in the blood. The sleep quality index scores showed improvement after the intervention of rice-based meal. In addition to the subjective assessment, blood plasma eotaxin-1 levels substantially reduced by the intervention. Several molecular studies demonstrated that eotaxin-1 impaired neurogenesis, synaptic plasticity and cognition, thus the molecule is suggested negative modifier of central nervous system. Although the relationship between sleep quality and blood plasma eotaxin-1 level has not been cleared so far, findings of the present study support that rice-based diet benefits brain health. PT740 Prediction of Circadian Clock with Combination of One point Expression Profiles of Ten Circadian Clock Genes of Circadian rhythm Prediction Model Taek Lee1,*, Soojin Kim2,*, Joung-Ho Moon3, Chul-Hyun Cho3, KyungSook Yang4, Hoh Peter In1, Dongho Geum2,+, Heon-Jeong Lee3,+, 1 Department of Computer Science, College of Information and Communications; 2 Department of Biomedical Sciences, College of Medicine; 3 Department of Psychiatry, College of Medicine; 4 Department of Biostatistics, College of Medicine, Korea University, Seoul 136–705,